So, what is mono, and what are the symptoms? American Family Care in Danbury has answers, and treatment, for you. Mononucleosis (mono) is an infectious viral disease most commonly caused by the Epstein-Barr virus (EBV), but other viruses can also cause it. Also sometimes known as the “kissing disease,” mono is spread through saliva and can even be passed from person to person from sharing cutlery and utensils. According to the CDC, mono occurs mainly ...